Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib

Although the development of tyrosine kinase inhibitors (TKIs) to control the unregulated activity of BCR-ABL revolutionized the therapy of chronic myeloid leukemia, resistance to TKIs is a clinical reality. Among the postulated mechanisms of resistance is the overexpression of ATP-binding cassette (...

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Main Authors: Dohse, Marius, Scharenberg, Christian, Shukla, Suneet, Robey, Robert W., Volkmann, Thorsten, Deeken, John F., Brendel, Cornelia, Ambudkar, Suresh V., Neubauer, Andreas, Bates, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913625/
https://ncbi.nlm.nih.gov/pubmed/20423956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.031302
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