DEATH RECEPTOR 5 INTERNALIZATION IS REQUIRED FOR LYSOSOMAL PERMEABILIZATION BY TRAIL IN MALIGNANT LIVER CELL LINES

BACKGROUND & AIMS: TRAIL cytotoxicity in hepatocellular carcinoma cells is mediated by lysosomal permeabilization. Our aims were to determine which TRAIL receptor, death receptor 4 or 5, mediates lysosomal permeabilization and assess whether receptor endocytosis followed by trafficking to lysoso...

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Hauptverfasser: Akazawa, Yuko, Mott, Justin L., Bronk, Steven F., Werneburg, Nathan W., Kahraman, Alisan, Guicciardi, Maria Eugenia, Meng, Xue Wei, Kohno, Shigeru, Shah, Vijay H., Kaufmann, Scott H., McNiven, Mark A., Gores, Gregory J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693420/
https://ncbi.nlm.nih.gov/pubmed/19272388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.02.071
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