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Bax inhibition protects against free fatty acid-induced lysosomal permeabilization

Lysosomal permeabilization is a key feature of hepatocyte lipotoxicity, yet the mechanisms mediating this critical cellular event are unclear. This study examined the mechanisms involved in free fatty acid (FFA)-induced lysosomal permeabilization and the role of Bax, a Bcl-2 family member, in this e...

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Hlavní autoři: Feldstein, Ariel E., Werneburg, Nathan W., Li, ZhengZheng, Bronk, Steven F., Gores, Gregory J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056273/
https://ncbi.nlm.nih.gov/pubmed/16484678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00509.2005
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