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Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
Lysosomal permeabilization is a key feature of hepatocyte lipotoxicity, yet the mechanisms mediating this critical cellular event are unclear. This study examined the mechanisms involved in free fatty acid (FFA)-induced lysosomal permeabilization and the role of Bax, a Bcl-2 family member, in this e...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056273/ https://ncbi.nlm.nih.gov/pubmed/16484678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00509.2005 |
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