Overexpression of Mcl-1 Attenuates Liver Injury and Fibrosis in the Bile Duct–Ligated Mouse

Hepatocyte apoptosis contributes to liver injury and fibrosis after cholestatic injury. Our aim was to ascertain if the anti-apoptotic protein Mcl-1 alters liver injury or fibrosis in the bile duct–ligated mouse. Markers of apoptosis and fibrosis were compared in wild-type and transgenic mice expres...

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Main Authors: Kahraman, Alisan, Mott, Justin L., Bronk, Steven F., Werneburg, Nathan W., Barreyro, Fernando J., Guicciardi, Maria E., Akazawa, Yuko, Braley, Karen, Craig, Ruth W., Gores, Gregory J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879585/
https://ncbi.nlm.nih.gov/pubmed/19051025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-008-0583-5
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