Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
Insolubility of full-length HIV-1 integrase (IN) limited previous structure analyses to individual domains. By introducing five point mutations, we engineered a more soluble IN that allowed us to generate multidomain HIV-1 IN crystals. The first multidomain HIV-1 IN structure is reported. It incorpo...
Sábháilte in:
| Foilsithe in: | Proc Natl Acad Sci U S A |
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| Príomhchruthaitheoirí: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
National Academy of Sciences
2000
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| Ábhair: | |
| Rochtain ar líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150220297 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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