Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
Insolubility of full-length HIV-1 integrase (IN) limited previous structure analyses to individual domains. By introducing five point mutations, we engineered a more soluble IN that allowed us to generate multidomain HIV-1 IN crystals. The first multidomain HIV-1 IN structure is reported. It incorpo...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150220297 |
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