Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

HIV integrase, the enzyme that inserts the viral DNA into the host chromosome, has no mammalian counterpart, making it an attractive target for antiviral drug design. As one of the three enzymes produced by HIV, it can be expected that inhibitors of this enzyme will complement the therapeutic use of...

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Detalhes bibliográficos
Main Authors: Goldgur, Yehuda, Craigie, Robert, Cohen, Gerson H., Fujiwara, Tamio, Yoshinaga, Tomokazu, Fujishita, Toshio, Sugimoto, Hirohiko, Endo, Takeshi, Murai, Hitoshi, Davies, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC23896/
https://ncbi.nlm.nih.gov/pubmed/10557269
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