Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium

HIV-1 integrase is an essential enzyme in the life cycle of the virus, responsible for catalyzing the insertion of the viral genome into the host cell chromosome; it provides an attractive target for antiviral drug design. The previously reported crystal structure of the HIV-1 integrase core domain...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Goldgur, Yehuda, Dyda, Fred, Hickman, Alison B., Jenkins, Timothy M., Craigie, Robert, Davies, David R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689049/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9150
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