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Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium

HIV-1 integrase is an essential enzyme in the life cycle of the virus, responsible for catalyzing the insertion of the viral genome into the host cell chromosome; it provides an attractive target for antiviral drug design. The previously reported crystal structure of the HIV-1 integrase core domain...

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Sonraí bibleagrafaíochta
Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Goldgur, Yehuda, Dyda, Fred, Hickman, Alison B., Jenkins, Timothy M., Craigie, Robert, Davies, David R.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 1998
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21307/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689049/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9150
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