Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium

HIV-1 integrase is an essential enzyme in the life cycle of the virus, responsible for catalyzing the insertion of the viral genome into the host cell chromosome; it provides an attractive target for antiviral drug design. The previously reported crystal structure of the HIV-1 integrase core domain...

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Bibliographic Details
Main Authors: Goldgur, Yehuda, Dyda, Fred, Hickman, Alison B., Jenkins, Timothy M., Craigie, Robert, Davies, David R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21307/
https://ncbi.nlm.nih.gov/pubmed/9689049
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