Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

Insolubility of full-length HIV-1 integrase (IN) limited previous structure analyses to individual domains. By introducing five point mutations, we engineered a more soluble IN that allowed us to generate multidomain HIV-1 IN crystals. The first multidomain HIV-1 IN structure is reported. It incorpo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Julian C.-H., Krucinski, Jolanta, Miercke, Larry J. W., Finer-Moore, Janet S., Tang, Ann H., Leavitt, Andrew D., Stroud, Robert M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10890912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.150220297
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