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Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the CCl(4) and thioacetamide models
BACKGROUND: Keratins 8 and 18 (K8/K18) are important hepatoprotective proteins. Animals expressing K8/K18 mutants exhibit a marked susceptibility to acute/subacute liver injury. K8/K18 variants predispose to human end-stage liver disease and associate with fibrosis progression during chronic hepatit...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692280/ https://ncbi.nlm.nih.gov/pubmed/18395095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.01.035 |
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