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Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory-Denk body formation
Mallory-Denk bodies (MDBs) are hepatocyte inclusions that are associated with poor liver disease prognosis. The intermediate filament protein keratin 8 (K8) and its cross-linking by transglutaminase-2 (TG2) are essential for MDB formation. K8 hyperphosphorylation occurs in association with liver inj...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Federation of American Societies for Experimental Biology
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3360158/ https://ncbi.nlm.nih.gov/pubmed/22362895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-198580 |
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