Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the CCl(4) and thioacetamide models

BACKGROUND: Keratins 8 and 18 (K8/K18) are important hepatoprotective proteins. Animals expressing K8/K18 mutants exhibit a marked susceptibility to acute/subacute liver injury. K8/K18 variants predispose to human end-stage liver disease and associate with fibrosis progression during chronic hepatit...

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Hauptverfasser: Strnad, Pavel, Tao, Guo-Zhong, Zhou, Qin, Harada, Masaru, Toivola, Diana M., Brunt, Elizabeth M., Omary, M. Bishr
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692280/
https://ncbi.nlm.nih.gov/pubmed/18395095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.01.035
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