Keratin Overexpression Levels Correlate with the Extent of Spontaneous Pancreatic Injury

Mutation of the adult hepatocyte keratins K8 and K18 predisposes to liver disease. In contrast, exocrine pancreas K8 and K18 are dispensable and are co-expressed with limited levels of membrane-proximal K19 and K20. Overexpression of mutant K18 or genetic ablation of K8 in mouse pancreas is well tol...

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Detalhes bibliográficos
Main Authors: Toivola, Diana M., Nakamichi, Ikuo, Strnad, Pavel, Michie, Sara A., Ghori, Nafisa, Harada, Masaru, Zeh, Karin, Oshima, Robert G., Baribault, Helene, Omary, M. Bishr
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276414/
https://ncbi.nlm.nih.gov/pubmed/18349119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070830
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