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ATR CONTRIBUTES TO CELL CYCLE ARREST AND SURVIVAL AFTER CISPLATIN BUT NOT OXALIPLATIN

The DNA cross-linking agents cisplatin and oxaliplatin are widely used in the treatment of human cancer. Lesions produced by these agents are widely known to activate the G(1) and G(2) cell cycle checkpoints. Less is known about the role of the intra-S phase checkpoint in the response to these agent...

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Détails bibliographiques
Auteurs principaux: Lewis, Kriste A., Lilly, Kia K., Reynolds, Evelyn A., Sullivan, William P., Kaufmann, Scott H., Cliby, William A.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2690640/
https://ncbi.nlm.nih.gov/pubmed/19372558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1135
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