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Studies in Mice Deficient for the Autoimmune Regulator (Aire) and Transgenic for the Thyrotropin Receptor Reveal a Role for Aire in Tolerance for Thyroid Autoantigens

The autoimmune regulator (Aire) mediates central tolerance for many autoantigens, and autoimmunity occurs spontaneously in Aire-deficient humans and mice. Using a mouse model of Graves’ disease, we investigated the role of Aire in tolerance to the TSH receptor (TSHR) in Aire-deficient and wild-type...

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Detalhes bibliográficos
Main Authors: Misharin, Alexander V., Nagayama, Yuji, Aliesky, Holly A., Rapoport, Basil, McLachlan, Sandra M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689795/
https://ncbi.nlm.nih.gov/pubmed/19264867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1690
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