Role of the transgenic human thyrotropin receptor A-subunit in thyroiditis induced by A-subunit immunization and regulatory T cell depletion

Transgenic BALB/c mice that express intrathyroidal human thyroid stimulating hormone receptor (TSHR) A-subunit, unlike wild-type (WT) littermates, develop thyroid lymphocytic infiltration and spreading to other thyroid autoantigens after T regulatory cell (T(reg)) depletion and immunization with hum...

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Bibliographic Details
Main Authors: Mizutori, Y, Nagayama, Y, Flower, D, Misharin, A, Aliesky, H A, Rapoport, B, McLachlan, S M
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2008
Subjects:
Translational Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633226/
https://ncbi.nlm.nih.gov/pubmed/18811696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03769.x
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