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Attenuation of Induced Hyperthyroidism in Mice by Pretreatment with Thyrotropin Receptor Protein: Deviation of Thyroid-Stimulating to Nonfunctional Antibodies

Graves’-like hyperthyroidism is induced by immunizing BALB/c mice with adenovirus expressing the thyrotropin receptor (TSHR) or its A-subunit. Nonantigen-specific immune strategies can block disease development and some reduce established hyperthyroidism, but these approaches may have unforeseen sid...

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מידע ביבליוגרפי
Main Authors: Misharin, Alexander V., Nagayama, Yuji, Aliesky, Holly A., Mizutori, Yumiko, Rapoport, Basil, McLachlan, Sandra M.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Endocrine Society 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717879/
https://ncbi.nlm.nih.gov/pubmed/19389831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0181
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