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Cyclic Pyrrole-Imidazole Polyamides Targeted to the Androgen Response Element
Hairpin pyrrole-imidazole polyamides are a class of cell-permeable DNA-binding small molecules that can disrupt transcription factor-DNA binding and regulate endogenous gene expression. The covalent linkage of antiparallel Py-Im ring pairs with an γ-amino acid turn unit affords the classical hairpin...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2689155/ https://ncbi.nlm.nih.gov/pubmed/19413319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja901309z |
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