Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity

IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of galactose-deficient IgA1 and a glycan-specific IgG antibody. These immune complexes deposit in the glomerular mesangium and induce the mesangioproliferative glomerulonephritis characteristic of IgAN. To define the pr...

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Autors principals: Suzuki, Hitoshi, Fan, Run, Zhang, Zhixin, Brown, Rhubell, Hall, Stacy, Julian, Bruce A., Chatham, W. Winn, Suzuki, Yusuke, Wyatt, Robert J., Moldoveanu, Zina, Lee, Jeannette Y., Robinson, James, Tomana, Milan, Tomino, Yasuhiko, Mestecky, Jiri, Novak, Jan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689118/
https://ncbi.nlm.nih.gov/pubmed/19478457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38468
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