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Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein

We recently derived a CD4-independent virus from HIV-1/IIIB, termed IIIBx, which interacts directly with the chemokine receptor CXCR4 to infect cells. To address the underlying mechanism, a cloned Env from the IIIBx swarm (8x) was used to produce soluble gp120. 8x gp120 bound directly to cells expre...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Hoffman, Trevor L., LaBranche, Celia C., Zhang, Wentao, Canziani, Gabriella, Robinson, James, Chaiken, Irwin, Hoxie, James A., Doms, Robert W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26886/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10339592/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.11.6359
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