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CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction between the CCR5 N Terminus and the gp120 C4 Domain

Envelope glycoproteins (Envs) of human immunodeficiency virus type 2 (HIV-2) are frequently able to use chemokine receptors, CXCR4 or CCR5, in the absence of CD4. However, while these Envs are commonly dual-tropic, no isolate has been described to date that is CD4 independent on both CXCR4 and CCR5....

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Библиографические подробности
Главные авторы: Lin, George, Lee, Benhur, Haggarty, Beth S., Doms, Robert W., Hoxie, James A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC114658/
https://ncbi.nlm.nih.gov/pubmed/11602718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.22.10766-10778.2001
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