Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding

CD4 and the chemokine receptors, CXCR4 and CCR5, serve as receptors for human immunodeficiency virus type 1 (HIV-1). Binding of the HIV-1 gp120 envelope glycoprotein to the chemokine receptors normally requires prior interaction with CD4. Mapping the determinants on gp120 for the low-affinity intera...

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Main Authors: Basmaciogullari, Stéphane, Babcock, Gregory J., Van Ryk, Donald, Wojtowicz, Woj, Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136628/
https://ncbi.nlm.nih.gov/pubmed/12368322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.21.10791-10800.2002
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