Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein

A CD4-independent version of the X4 human immunodeficiency virus type 1 (HIV-1) HXBc2 envelope (Env) protein, termed 8x, mediates infection of CD4-negative, CXCR4-positive cells, binds directly to CXCR4 in the absence of CD4 due to constitutive exposure of a conserved coreceptor binding site in the...

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Main Authors: Edwards, Terri G., Hoffman, Trevor L., Baribaud, Frédéric, Wyss, Stéphanie, LaBranche, Celia C., Romano, Josephine, Adkinson, Joshua, Sharron, Matthew, Hoxie, James A., Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC114929/
https://ncbi.nlm.nih.gov/pubmed/11333905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.11.5230-5239.2001
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