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β-Lactam-based Approach for the Chemical Programming of Aldolase Antibody 38C2
Irreversible chemical programming of monoclonal aldolase antibody (mAb) 38C2 has been accomplished with β-lactam equipped targeting modules. A model study was first performed with β-lactam conjugated to biotin. This conjugate efficiently and selectively modified the catalytic site lysine (LysH93) of...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688461/ https://ncbi.nlm.nih.gov/pubmed/19181522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.01.028 |
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