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Intracellular Localization of the ABCC Proteins of Leishmania and Their Role in Resistance to Antimonials

The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Le...

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Bibliographic Details
Main Authors: Leprohon, Philippe, Légaré, Danielle, Ouellette, Marc
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687239/
https://ncbi.nlm.nih.gov/pubmed/19307364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01474-08
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