Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum

Antimonials remain the first line drug against the protozoan parasite Leishmania but their efficacy is threatened by resistance. We carried out a RNA expression profiling analysis comparing an antimony-sensitive and -resistant (Sb2000.1) strain of Leishmania infantum using whole-genome 70-mer oligon...

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Bibliographische Detailangaben
Hauptverfasser: Leprohon, Philippe, Légaré, Danielle, Raymond, Frédéric, Madore, Éric, Hardiman, Gary, Corbeil, Jacques, Ouellette, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655676/
https://ncbi.nlm.nih.gov/pubmed/19129236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1069
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