Gene Amplification and Point Mutations in Pyrimidine Metabolic Genes in 5-Fluorouracil Resistant Leishmania infantum

BACKGROUND: The human protozoan parasites Leishmania are prototrophic for pyrimidines with the ability of both de novo biosynthesis and uptake of pyrimidines. METHODOLOGY/PRINCIPAL FINDINGS: Five independent L. infantum mutants were selected for resistance to the pyrimidine analogue 5-fluorouracil (...

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Главные авторы: Ritt, Jean-François, Raymond, Frédéric, Leprohon, Philippe, Légaré, Danielle, Corbeil, Jacques, Ouellette, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836990/
https://ncbi.nlm.nih.gov/pubmed/24278495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002564
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