Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp....

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Bibliografiske detaljer
Main Authors: Coelho, Adriano C., Messier, Nadine, Ouellette, Marc, Cotrim, Paulo C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932501/
https://ncbi.nlm.nih.gov/pubmed/17452480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00404-07
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