Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp....

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Bibliographic Details
Main Authors: Coelho, Adriano C., Messier, Nadine, Ouellette, Marc, Cotrim, Paulo C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932501/
https://ncbi.nlm.nih.gov/pubmed/17452480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00404-07
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