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Role of the ABC Transporter PRP1 (ABCC7) in Pentamidine Resistance in Leishmania Amastigotes

Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp....

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Detalhes bibliográficos
Main Authors: Coelho, Adriano C., Messier, Nadine, Ouellette, Marc, Cotrim, Paulo C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932501/
https://ncbi.nlm.nih.gov/pubmed/17452480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00404-07
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