The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

Ectopic repression of retinoic acid (RA) receptor target genes by PML/RARA and PLZF/RARA fusion proteins through aberrant recruitment of nuclear corepressor complexes drives cellular transformation and acute promyelocytic leukemia (APL) development. In the case of PML/RARA, this repression can be re...

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Main Authors: Boukarabila, Hanane, Saurin, Andrew J., Batsché, Eric, Mossadegh, Noushine, van Lohuizen, Maarten, Otte, Arie P., Pradel, Jacques, Muchardt, Christian, Sieweke, Michael, Duprez, Estelle
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2009
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685534/
https://ncbi.nlm.nih.gov/pubmed/19451220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.512009
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