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The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

Proteins of the GW182 family are essential components of the miRNA pathway in animal cells. Vertebrate genomes encode three GW182 paralogs (TNRC6A, TNRC6B, and TNRC6C), which may be functionally redundant. Here, we show that the N-terminal GW-repeat-containing regions of all three TNRC6s interact wi...

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主要な著者: Lazzaretti, Daniela, Tournier, Isabelle, Izaurralde, Elisa
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685519/
https://ncbi.nlm.nih.gov/pubmed/19383768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1606309
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