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TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses

We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically down-regulated in CD4(+) and CD8(+) primary human T cells upon T cell activation....

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Detalhes bibliográficos
Main Authors: Arimura, Yutaka, Vang, Torkel, Tautz, Lutz, Williams, Scott, Mustelin, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685193/
https://ncbi.nlm.nih.gov/pubmed/18457880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.03.019
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