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TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses
We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically down-regulated in CD4(+) and CD8(+) primary human T cells upon T cell activation....
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685193/ https://ncbi.nlm.nih.gov/pubmed/18457880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.03.019 |
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