The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses

The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in Caucasians. Although the disease-associated LYP allele (LYP*W620) is a gain-of-function variant that has higher catalytic ac...

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Main Authors: Vang, Torkel, Landskron, Johannes, Viken, Marte K., Oberprieler, Nikolaus, Torgersen, Knut M., Mustelin, Tomas, Tasken, Kjetil, Tautz, Lutz, Rickert, Robert C., Lie, Benedicte A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011173/
https://ncbi.nlm.nih.gov/pubmed/23333624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humimm.2012.12.017
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