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Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

The envelope glycoprotein of human immunodeficiency virus (HIV) consists of an exterior glycoprotein (gp120) and a trans-membrane domain (gp41) and has an important role in viral entry into cells. HIV-1 entry has been validated as a clinically relevant anti-viral strategy for drug discovery. In the...

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Detalhes bibliográficos
Main Authors: Zhou, Jiehua, Swiderski, Piotr, Li, Haitang, Zhang, Jane, Neff, C. Preston, Akkina, Ramesh, Rossi, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685106/
https://ncbi.nlm.nih.gov/pubmed/19304999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp185
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