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90-kDa Heat Shock Protein Inhibition Abrogates the Topoisomerase I Poison-Induced G(2)/M Checkpoint in p53-Null Tumor Cells by Depleting Chk1 and Wee1
The G(2)/M cell cycle checkpoint is regulated by a multitude of signaling pathways after genotoxic stress. Herein, we report that treatment with the 90-kDa heat shock protein (Hsp90) molecular chaperone inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) selectively abrogates the G(2)/M checkpo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2685054/ https://ncbi.nlm.nih.gov/pubmed/18820127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.050807 |
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