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Adeno-Associated Virus-2 and its Primary Cellular Receptor – Cryo-EM Structure of a Heparin Complex
Adeno-associated virus serotype 2 (AAV-2) is a leading candidate vector for gene therapy. Cell entry starts with attachment to a primary receptor, Heparan Sulfate Proteoglycan (HSPG) before binding to a co-receptor. Here, cryo-electron microscopy provides direct visualization of the virus–HSPG inter...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2684845/ https://ncbi.nlm.nih.gov/pubmed/19144372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.11.037 |
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