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Characterization of Interactions between Heparin/Glycosaminoglycan and Adeno-associated Virus

Adeno-associated virus (AAV) is a key candidate in the development of gene therapy. In this report, we used surface plasmon resonance spectroscopy to study the interaction between AAV and heparin and other glycosaminoglycans. Surface plasmon resonance results revealed that heparin binds to AAV with...

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Detalhes bibliográficos
Main Authors: Zhang, Fuming, Aguilera, Javier, Beaudet, Julie M., Xie, Qing, Lerch, Thomas F., Davulcu, Omar, Colón, Wilfredo, Chapman, Michael S., Linhardt, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859860/
https://ncbi.nlm.nih.gov/pubmed/23952613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4008676
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