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Adeno-Associated Virus-2 and its Primary Cellular Receptor – Cryo-EM Structure of a Heparin Complex

Adeno-associated virus serotype 2 (AAV-2) is a leading candidate vector for gene therapy. Cell entry starts with attachment to a primary receptor, Heparan Sulfate Proteoglycan (HSPG) before binding to a co-receptor. Here, cryo-electron microscopy provides direct visualization of the virus–HSPG inter...

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Hlavní autoři: O'Donnell, Jason, Taylor, Kenneth A., Chapman, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684845/
https://ncbi.nlm.nih.gov/pubmed/19144372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.11.037
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