structurE of adeno-associated virus-2 In Complex with Neutralizing Monoclonal antibodY A20

The use of adeno-associated virus (AAV) as a gene therapy vector is limited by the host neutralizing immune response. The cryo-electron microscopy (EM) structure at 8.5 Å resolution is determined for a complex of AAV-2 with the Fab′ fragment of monoclonal antibody (MAb) A20, the most extensively cha...

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Bibliographic Details
Main Authors: McCraw, Dustin M., O’Donnell, Jason K., Taylor, Kenneth A., Stagg, Scott M., Chapman, Michael S.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383000/
https://ncbi.nlm.nih.gov/pubmed/22682774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.05.004
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