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AZD1152 rapidly and negatively affects the growth and survival of Human AML cells in vitro and in vivo

Aurora kinases play a critical role in regulating mitosis and cell division and there over expression have been implicated in the survival and proliferation of human cancer. In this study we report the in vitro and in vivo activities of AZD1152, a compound that has selectivity for aurora B kinase, i...

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Dettagli Bibliografici
Autori principali: Oke, Adedayo, Pearce, Daniel, Wilkinson, Robert W., Crafter, Claire, Odedra, Rajesh, Cavenagh, Jamie, Fitzgibbon, Jude, Lister, Andrew T., Joel, Simon, Bonnet, Dominique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684546/
https://ncbi.nlm.nih.gov/pubmed/19366807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3203
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