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Enhanced Radiosensitivity of Androgen-Resistant Prostate Cancer: AZD1152-Mediated Aurora Kinase B Inhibition

Aurora kinase B (AURKB) is critical to the process of mitosis, aiding in chromosome condensation by phosphorylating histone H3. We investigated the effects of AZD1152, an AURKB inhibitor, on radiosensitivity of androgen-insensitive prostate cancer cells. The goal of this study was to test whether AZ...

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Autors principals: Niermann, Kenneth J., Moretti, Luigi, Giacalone, Nicholas J., Sun, Yunguang, Schleicher, Stephen M., Kopsombut, Prapaporn, Mitchell, Lauren R., Kim, Kwang Woon, Lu, Bo
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133747/
https://ncbi.nlm.nih.gov/pubmed/21222513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR2317.1
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