Barasertib (AZD1152), a small molecule Aurora B inhibitor, inhibits the growth of SCLC cell lines in vitro and in vivo

Small cell lung cancer (SCLC) cells have rapid proliferation, universal Rb inactivation and high rates of MYC family amplification, making aurora kinase inhibition a natural target. Preclinical studies have demonstrated activity for Aurora A and pan Aurora inhibitors with some relationship to MYC fa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cancer Ther
Egile Nagusiak: Helfrich, Barbara A, Kim, Jihye, Gao, Dexiang, Chan, Daniel C, Zhang, Zhiyong, Tan, Aik-Choon, Bunn, Paul A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050114/
https://ncbi.nlm.nih.gov/pubmed/27496133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0298
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