Phase I study assessing the safety and tolerability of barasertib (AZD1152) with low-dose cytosine arabinoside in elderly patients with AML

INTRODUCTION: Barasertib is the pro-drug of barasertib-hQPA, a selective Aurora B kinase inhibitor that has demonstrated preliminary anti-acute myeloid leukemia (AML) activity in the clinical setting. METHODS: This Phase I dose-escalation study evaluated the safety and tolerability of barasertib, co...

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Main Authors: Kantarjian, Hagop M, Sekeres, Mikkael A, Ribrag, Vincent, Rousselot, Philippe, Garcia-Manero, Guillermo, Jabbour, Elias J, Owen, Kate, Stockman, Paul K, Oliver, Stuart D
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775947/
https://ncbi.nlm.nih.gov/pubmed/23763917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clml.2013.03.019
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