Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer

BACKGROUND: AZD1152, the prodrug for AZD1152-hydroxyquinazoline pyrazol anilide (HQPA), is a selective inhibitor of Aurora B kinase activity. Preclinical evaluation of AZD1152 has been reported in several human cancer models. The potentiality of this compound in combination therapy warrants further...

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Detalhes bibliográficos
Main Authors: Azzariti, A, Bocci, G, Porcelli, L, Fioravanti, A, Sini, P, Simone, G M, Quatrale, A E, Chiarappa, P, Mangia, A, Sebastian, S, Del Bufalo, D, Del Tacca, M, Paradiso, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048212/
https://ncbi.nlm.nih.gov/pubmed/21304529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.21
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