Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells

The new combination between the nucleoside analogue gemcitabine and the cholesterol-lowering drug fluvastatin was investigated in vitro and in vivo on the human pancreatic tumour cell line MIAPaCa-2. The present study demonstrates that fluvastatin inhibits proliferation, induces apoptosis in pancrea...

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Hlavní autoři: Bocci, G, Fioravanti, A, Orlandi, P, Bernardini, N, Collecchi, P, Del Tacca, M, Danesi, R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2005
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361561/
https://ncbi.nlm.nih.gov/pubmed/16052215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602720
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