Soluble Epoxide Inhibition Is Protective Against Cerebral Ischemia via Vascular and Neural Protection

Inhibition of soluble epoxide hydrolase (SEH), the enzyme responsible for degradation of vasoactive epoxides, protects against cerebral ischemia in rats. However, the molecular and biological mechanisms that confer protection in normotension and hypertension remain unclear. Here we show that 6 weeks...

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Main Authors: Simpkins, Alexis N., Rudic, R. Daniel, Schreihofer, Derek A., Roy, Sid, Manhiani, Marlina, Tsai, Hsing-Ju, Hammock, Bruce D., Imig, John D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2009
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2684174/
https://ncbi.nlm.nih.gov/pubmed/19435785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080544
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