Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension

Inhibition of soluble epoxide hydrolase (sEH) has been shown to be renal protective in rat models of salt-sensitive hypertension. Here, we hypothesize that targeted disruption of the sEH gene (Ephx2) prevents both renal inflammation and injury in deoxycorticosterone acetate plus high salt (DOCA-salt...

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Bibliografiske detaljer
Main Authors: Manhiani, Marlina, Quigley, Jeffrey E., Knight, Sarah F., Tasoobshirazi, Shiva, Moore, TarRhonda, Brands, Michael W., Hammock, Bruce D., Imig, John D.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739707/
https://ncbi.nlm.nih.gov/pubmed/19553349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00098.2009
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