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Interferon-gamma Dictates Allograft Fate via Opposing Effects on the Graft and on Recipient CD8 T-cell Responses
CD8 T cells are necessary for costimulation blockade-resistant rejection. However, the mechanism by which CD8 T cells mediate rejection in the absence of major costimulatory signals is poorly understood. IFNγ promotes CD8 T cell-mediated immune responses, but IFNγ-deficient mice show early graft los...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683416/ https://ncbi.nlm.nih.gov/pubmed/19109153 |
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